Folate Pathway Gene Methylenetetrahydrofolate Reductase C677T Polymorphism and Alzheimer Disease Risk in Asian Population.

Abstract

The association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and susceptibility to Alzheimers disease (AD) was controversial in previous studies. The present meta-analysis was designed to investigate the association of MTHFR C677T polymorphism with AD. Nine studies were identified by search of PubMed, Google Scholar, Elsevier, Springer Link databases, up to January 2013. Odds ratios (ORs) with corresponding 95% confidence interval (CI) were calculated using fixed effects model or random effects model. All statistical analysis was done by Mix version 1.7. MTHFR C677T polymorphism had a significant association with susceptibility to AD in all genetic models (for T vs C: OR 1.29, 95% CI 1.15-1.44, p<0.0001; for TT+CT vs CC: OR 1.38, 95% CI 1.16-1.364, p=0.0002; for TT vs CC: OR 1.60, 95% CI 1.25-2.04, p=0.0001; for CT vs CC: OR 1.28, 95% CI 1.1-1.53, p<0.008; for TT vs CT+CC: OR 1.37, 95% CI 1.12-1.67, p=0.002). Results from present meta-analysis supported that the MTHFR C677T polymorphism was associated with an increased risk of AD in Asian population.