Folate and vitamin B 12 are dietary essential vitamins required for human health. Folate functions as a cofactor in the synthesis of nucleotides required for DNA synthesis and in amino acid metabolism including the synthesis of the methyl group of methionine, an amino acid used extensively in methylation reactions. Vitamin B 12 metabolism interacts with folate metabolism as it is also a cofactor in synthesis of methionine and the catabolism of other amino acids. The classic symptom of both folate and vitamin B 12 deficiency is an identical megoloblastic (large cell) anemia, which is a reflection of defective DNA synthesis. Vitamin B 12 deficiency can also cause subacute combined disease, a severe demyelination condition. The finding that periconceptional folate supplementation greatly reduced the incidence of birth defects such as spina bifida in humans has led to fortification of the food supply with folic acid in the United States and over 50 other countries.
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Round-ups are the summaries of handpicked papers around trending topics published every week. These would enable you to scan through a collection of papers and decide if the paper is relevant to you before actually investing time into reading it.
Climate change Research Articles published between Aug 08, 2022 to Aug 14, 2022
Aug 15, 2022
Articles Included: 5
Introduction: There is no consensus on the policies that should be seen as implicitly pricing carbon (see World Bank (2019a) for a discussion). The OE...Read More
Gender Equality Research Articles published between Aug 08, 2022 to Aug 14, 2022
Aug 15, 2022
Articles Included: 4
I would like to thank Anna Khakee, Federica Zardo and Ragnar Weilandt for their very useful comments as well as the participants of the workshop of 21...Read More
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