Folate and vitamin B 12 are dietary essential vitamins required for human health. Folate functions as a cofactor in the synthesis of nucleotides required for DNA synthesis and in amino acid metabolism including the synthesis of the methyl group of methionine, an amino acid used extensively in methylation reactions. Vitamin B 12 metabolism interacts with folate metabolism as it is also a cofactor in synthesis of methionine and the catabolism of other amino acids. The classic symptom of both folate and vitamin B 12 deficiency is an identical megoloblastic (large cell) anemia, which is a reflection of defective DNA synthesis. Vitamin B 12 deficiency can also cause subacute combined disease, a severe demyelination condition. The finding that periconceptional folate supplementation greatly reduced the incidence of birth defects such as spina bifida in humans has led to fortification of the food supply with folic acid in the United States and over 50 other countries.
Spina Bifida In Humans Vitamin B12 Synthesis Of Methionine Folate Metabolism Spina Bifida Methylation Reactions Amino Acid Folic Acid Catabolism Of Amino Acids Large Cell
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Round-ups are the summaries of handpicked papers around trending topics published every week. These would enable you to scan through a collection of papers and decide if the paper is relevant to you before actually investing time into reading it.
Climate change Research Articles published between Jan 23, 2023 to Jan 29, 2023
Jan 30, 2023
Articles Included: 3
Climate change adaptation has shifted from a single-dimension to an integrative approach that aligns with vulnerability and resilience concepts. Adapt...Read More
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