Abstract
Limbal stem cells (LSCs) transplantation is an effective surgical treatment to address limbal stem cells deficiency (LSCD) resulting from Stevens Johnson's syndrome or corneal chemical burn.LSCs transplantation has been reported as the successful stem cell therapy for bodybuilding, while it still faces a number of daunting challenges.Researchers should pay more attention to substitute seed cell, novel cell carrier materials, effective expansion method, niche modification and immune rejection, so that patients with ocular surface diseases would get fullly therapeutic benefit. Key words: Limbal stem cells; Immunologic rejection; Niche
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