Focus on Proteomics and Bioinformatics in Translational Research and Plant Research of Obesity and Diabetes

Abstract

Obesity and diabetes are diseases that emerge as serious health problems to our dayto-day life. In both developed and developing countries the share of public health expenditures for diabetes and obesity increases rapidly. This results in an intense expansion of research in the area of the pathogenesis of these diseases. Translational research which defines studies where knowledge obtained in research laboratories is used to understand the molecular bases of these diseases and implement it for clinical applications is a major part of efforts to have knowledge of and potentially cure obesity and diabetes. Additionally, there is a significant number of studies researching on the potential use of plants and plant extracts to cure these two metabolic anomalies. In this context, concepts of plant biotechnology and medicinal plants began to gain a special importance in the area. The supply of a considerable number of information based on translational and plant research on the field of diabetes and obesity made it inevitable to make use of the advantages of proteomics and bioinformatics. We in our mini review focused on the studies regarding obesity and diabetes in a frame of translational research and plant research. We also highlighted the importance of proteomics and bioinformatics for the systematic dissection of accumulated data on the pathogenesis of these diseases.