Abstract
Understanding the molecular and neuroanatomical underpinnings of mood disorders such as depression and anxiety may help to develop diagnostic tools or to identify alternative targets for drug discovery. Mood disorders share comorbidities with pain syndromes. Clinically, a principal mood disturbance can enhance pain perception, whereas primary pain pathologies can aggravate mood disorders. Such comorbidities can be studied in animal models, thereby offering alternative tools to investigate molecular mechanisms inducing depression and to support the development of tailored treatments for depressive patients. Cingulate Overexpression of Mitogen-Activated Protein Kinase Phosphatase-1 as a Key Factor for DepressionBiological PsychiatryVol. 82Issue 5PreviewDepression is frequently associated with chronic pain or chronic stress. Among cortical areas, the anterior cingulate cortex (ACC, areas 24a and 24b) appears to be important for mood disorders and constitutes a neuroanatomical substrate for investigating the underlying molecular mechanisms. The current work aimed at identifying ACC molecular factors subserving depression. Full-Text PDF
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