Focal Segmental Glomerulosclerosis Secondary to Hodgkin’s Lymphoma: A Case Report

Abstract

Focal segmental glomerulosclerosis (FSGS) accounts for 12-35% of nephrotic syndrome (NS) in adult. The association between FSGS and Hodgkin’s disease is rare. NS may precede, be concomitant with or appear secondary to Hodgkin’s lymphoma. We report a case of a 57-year-old patient who was admitted with impure NS with 7g/24h of proteinuria, renal failure and microscopic haematuria, revealing FSGS on renal biopsy, with concomitant discovery of Hodgkin’s lymphoma of sclero-nodular type. Treatment of Hodgkin’s lymphoma with chemotherapy led to disappearance of the NS and complete recovery of renal function. The association of FSGS and Hodgkin lymphoma, although rare, is not a myth but a reality. Histology and imaging are important diagnostic tools. Early initiation of specific chemotherapy is a fundamental condition for complete recovery of renal function.