Abstract
Hepatic hemangioma, adenoma and focal nodular hyperplasia are the most frequent benign lesions of the liver, but they are all infrequent among pediatric population. The reports of focal nodular hyperplasia in children have recently increased in number, with many cases associated to drug intake, particularly to chemotherapy. We here describe, to our knowledge, the first case of focal nodular hyperplasia in association with diabetes mellitus in childhood.
Highlights
The focal nodular hyperplasia (FNH) first described by Edmondson in 1956, accounts for 8% of primary hepatic tumors in adults and less than 2% in children
FNH is very rare in pediatric population with an age prevalence in children 7-8 years old, some cases are diagnosed in early childhood or even in the prenatal period [3]
The cause is unknown the hypothesis that obstruction of hepatic vessels or abnormal vascularization could account for FNH is suggested by the reported association with clinical and anatomic findings like hypoplasia or agenesis of the portal vein, vascular malformations, hemangioma and vascular dysplasia, Budd-Chiari syndrome and hereditary hemorrhagic telangiectasia [5,6]
Summary
The focal nodular hyperplasia (FNH) first described by Edmondson in 1956, accounts for 8% of primary hepatic tumors in adults and less than 2% in children. CT scan (Fig. 1A, B) confirmed the presence of two masses, with an evidence of tumor capsule, that, after contrast injection, were hyperdense in early (arterial) phase and isodense, compared to the remaining liver parenchyma, in venous phase; it highlighted a central hypodense "scar".
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