Foams as unique drug delivery systems

Abstract

Foams are multiphase systems found throughout nature. We meet them equally often in our everyday life, starting with the foam in the morning espresso, where the foam should constitute 10% of the drink or in a glass of beer and ending with the evening bath with foam. These multiphase systems consist mainly of gas, which is separated by liquid or solid lamellae. The lamellae have a very large surface area and a small thickness, which results in their low stability. The foams in pharmaceutics are known for a long time as protective or therapeutic preparations for topical use. However, the physicochemical structure of both solid and liquid foams offers multiple fields of application in the modern therapy. For instance, owing to the unique structure, foams can be also used for parenteral use in the form of implants serving as a drug carrier and at the same time, a scaffold for regenerating the tissue. Foams can also be used orally in the form of controlled drug delivery systems that are potentially useful for sustained or targeted drug delivery. The article describes the unique advantages and features of foams that make them useful in modern pharmacotherapy.