Abstract
Eight different antifoam agents were added in shake flasks or in a 50 L fermenter, and the foam control abilities and effects on cultures were evaluated in this paper. Results showed that THIX-298 and SXP107 antifoam agents could eliminate foam rapidly and suppress foam during the fermentation process in the shake flasks. The biomasses and yields of epothilones were affected by different antifoam agents’ addition when 0.06 % (v/v) THIX-298 antifoam agent was added in the shake flasks. The yields of epothilone A and B had a significant increase of about 48.12 and 48.55 % compared to the control, respectively, representing the largest effects of the antifoam agents tested. Reducing sugar and amino nitrogen were also utilized more rapidly than the control. Additionally, efficiency parameters of the different antifoam agents were compared in the fermentor. Finally, THIX-298 antifoam agent was chosen as the optimal one.
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