Abstract
Currently, breast cancer treatment mostly revolves around radiation therapy and surgical interventions, but often these treatments do not provide satisfactory relief to the patients and cause unmanageable side-effects. Nanomaterials show promising results in treating cancer cells and have many advantages such as high biocompatibility, bioavailability and effective therapeutic capabilities. Interestingly, fluorescent magnetic nanoparticles have been used in many biological and diagnostic applications, but there is no report of use of fluorescent magnetic submicronic polymer nanoparticles (FMSP-nanoparticles) in the treatment of human breast cancer cells. In the present study, we tested the effect of FMSP-nanoparticles on human breast cancer cells (MCF-7). We tested different concentrations (1.25, 12.5 and 50 µg/mL) of FMSP-nanoparticles in MCF-7 cells and evaluated the nanoparticles response morphometrically. Our results revealed that FMSP-nanoparticles produced a concentration dependent effect on the cancer cells, a dose of 1.25 µg/mL produced no significant effect on the cancer cell morphology and cell death, whereas dosages of 12.5 and 50 µg/mL resulted in significant nuclear augmentation, disintegration, chromatic condensation followed by dose dependent cell death. Our results demonstrate that FMSP-nanoparticles induce cell death in MCF-7 cells and may be a potential anti-cancer agent for breast cancer treatment.
Highlights
Breast cancer is the most commonly diagnosed cancer in women and one of the major reasons of cancer death among women
(Interestingly, fluorescent magnetic nanoparticles have been used in a wide range of applications in biological systems such as diagnostic, bioimaging, and drug delivery [27–45] and in the detection of foodborne pathogens [46]), but there is no report of use of fluorescent magnetic submicronic polymer nanoparticles (FMSP-nanoparticles) in the treatment of human breast cancer cells
scanning electron microscopy (SEM) analysis showed that nanoparticles were crystallized and spherical in shape (Figure 1); Biomolecules
Summary
Breast cancer is the most commonly diagnosed cancer in women and one of the major reasons of cancer death among women. The cancer is treated with chemotherapy, hormonal therapy, targeted therapy, and immunotherapy modalities, but all of them carry some side effects and shortcomings [3,4]. The reason for these shortcomings and side-effects are mostly due to non-specificity and systemic toxicity of anti-cancer drugs [5–7]. The major cause of the failure of current drug therapy, is the high rate of drug resistance of cancer cells [8]. Considering these issues, there is an urgent need for an alternative approach towards cancer management and treatment.
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