Abstract
The mesolimbic dopaminergic reward system is responsible for the affective negative symptomatology of schizophrenia which might be related to a low dopamine tonus within the ventral striatum. Using the monetary incentive delay (MID) task, activation of the ventral striatum to incentive stimuli can be studied in an excellent way. In patients with schizophrenia, activation of ventral striatum was low and related to primary and secondary (induced by neuroleptics) negative symptoms. Switching medication from typical to atypical neuroleptics, activation of ventral striatum increased due to lower D2 receptor blockade. Such studies show that fMRI tasks are well suitable to investigate important aspects of schizophrenia pathophysiology.
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