FMRI 데이터를 이용한 알츠하이머 진행상태 분류

Abstract

The development of functional magnetic resonance imaging (fMRI) has significantly contributed to mapping brain functions and understanding brain networks during rest. This paper proposes a CNN-LSTM-based classification model to classify the progression stages of Alzheimer's disease. Firstly, four preprocessing steps are performed to remove noise from the fMRI data before feature extraction. Secondly, the U-Net architecture is utilized to extract spatial features once preprocessing is completed. Thirdly, the extracted spatial features undergo LSTM processing to extract temporal features, ultimately leading to classification. Experiments were conducted by adjusting the temporal dimension of the data. Using 5-fold cross-validation, an average accuracy of 96.4% was achieved, indicating that the proposed method has high potential for identifying the progression of Alzheimer's disease by analyzing fMRI data.