Abstract
Fmoc amino acid fluorides were found to be exceptionally well suited for the coupling of extremely hindered amino acids using a new strategy involving treatment with bis(trimethylsilyl)acetamide prior to the acylation step. Addition of bis(trimethylsilyl)acetamide (BSA) accelerates peptide bond formation of extremely hindered amino acids. Fmoc-NMeAib-F + Aib-OMe + BSA → Fmoc-NMeAib-Aib-OMe Yield: 34%, 2h (without BSA: 8%)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
