Fluoxetine Reduces Saccharin-Induced Elevation of Fluid Intake in Alcohol-Preferring Fawn-Hooded Rats

Abstract

KAMPOV-POLEVOY, A. B. AND A. H. REZVANI. Fluoxetine reduces saccharin-induced elevation of fluid intake in alcohol-preferring Fawn-Hooded rats. PHARMACOL BIOCHEM BEHAV 58 [1] 51–54, 1997.—Previous work has established that saccharin and alcohol intakes are highly correlated in a variety of rat strains. In addition, it has been shown that alcohol-preferring rats consume saccharin beyond the limit of their normal daily fluid intake (DFI). It has been hypothesized that alcohol-preferring rats have impaired control over consumption of reinforcing substances, which may be related to a deficiency of brain serotonin. In the present study, we examined the effect of the serotonin reuptake inhibitor fluoxetine (2.5, 5.0, 10.0 mg/kg, IP, twice a day) on saccharin intake in alcohol-preferring Fawn-Hooded (FH) rats. It was confirmed that alcohol preferring FH rats almost triple their DFI when saccharin/water choice was introduced. Treatment with fluoxetine resulted in a dose-dependent decrease in saccharin intake to, but not below, the normal level of their DFI. No significant effects of fluoxetine on water intake were observed. Despite a significant (up to 69%) decrease in saccharin intake, only a minimal reduction (<4%) in saccharin preference occurred. We conclude that fluoxetine reduces the exessive elevation of fluid intake observed at the presence of the palatable saccharin solution in Fawn-Hooded rats. These findings may provide more evidence for the involvement of the serotonergic system in the brain in exessive drinking of rewarding substances.