Abstract
The hypotensive action of Fluothane in cats receiving autonomic blocking agents was compared with the response in unblocked cats. No effect on reflex mechanisms, the vasomotor centre, sympathetic ganglia, or nerve endings appears to play any part in the production of hypotension in the cat. Cardiac output in the intact animal receiving Fluothane was measured. From a consideration of both groups of experiments it would seem likely that Fluothane exerts its hypotensive effect by means of action on the heart and the arterioles. Coincident depression of respiration occurs.
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