Abstract

Tag team: Not only hydrophilic carbohydrates but also hydrophobic compounds such as histone deacetylase inhibitors and biotin can be incorporated into fluorous-based small-molecule microarrays. A range of fluorous-tagged molecules can be patterned and screened for bioactivity on a fluorous surface with hit rates comparable to those seen by solution-based and surface plasmon resonance-based bioassays.

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