Fluorous mixture synthesis of fluorous-Fmoc reagents using a one-pot double tagging strategy

Abstract

The concise synthesis of fluorous Fmoc (f-Fmoc) reagents bearing C3F7 or C4F9 or C6F13 chains were achieved by fluorous mixture synthesis. The fluorous tagging process was effectively conducted using Heck type reaction of the bis-diazonium salt and the corresponding fluorous olefine, each bearing a different fluorous tag, by a one-pot double tagging strategy. At the final stage, each f-Fmoc reagent was separated from the mixture of three f-Fmoc reagents by fluorous solid phase extraction.