Abstract
Abstract The synthesis of a glycopeptide was easily achieved by an Fmoc-strategy based on fluorous chemistry. In this study, hCG(β12-16) having an N-acetylglucosamine was synthesized in good yield using Fmoc-Asn(GlcNAc)-OH without protection of the sugar hydroxy groups by the dimethylphosphinothioic mixed anhydride (Mpt-MA) method. Each synthetic intermediate was able to be easily purified by simple fluorous-organic solvent extraction and monitored by TLC, NMR, and MS.
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