Abstract
A fluorometric method for determining guanisoquin in plasma, urine, and tissues, based upon the coupling of guanisoquin with ninhydrin in alkaline solution to form a highly fluorescent product, is described. Limited studies of the excretion and distribution in the rat and the dog indicated that the drug is very poorly absorbed orally, rapidly removed from the blood, and extensively bound to most tissues, with the exception of brain and adipose tissue.
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