Abstract
Spontaneously hypertensive rat (SHR) is an inbred rat line developing arterial hypertension early in life, accepted as a model for human essential hypertension1. It was found recently, that additional characteristics of SHR rats is avoidance of ethanol consumption in free-choice conditions2. One reason for such avoidance may be different activity of aldehyde-metabolizing enzymes, as observed in ALDH-2 deficient humans3 and animal models4,5. In the present work, we examine the activity of ethanol-metabolizing enzymes, alcohol dehydrogenase (ADH, E.C.1.1.1.1.) and aldehyde dehydrogenase (ALDH, E.C.1.2.1.3.), as well as aldehyde oxidase (AldOx) in some organs of SHR rats, and compare them to those obtained for the outbred Wistar rats.
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