Abstract
A binary Ni/Eu catalytic system has been developed, which enables an efficient reductive dicarbofunctionalization of unactivated alkenes with alkyl halides and malononitriles. The combination of Ni electron-shuttle catalysis with Eu(OTf)3, a non-redox-type Lewis acid, effectively activates the iminyl radicals, enabling the direct formation of the C(sp3)-C(sp3) bond and β-ketonitrile functionality across a variety of C═C double bonds. This reaction allows for the expedient synthesis of densely functionalized cyclic β-ketonitriles bearing all-carbon quaternary centers.
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