Abstract
The aim of this work was to develop a method to produce 18F-labeled fluorine gas ([ 18F]F 2) with high specific radioactivity (SA, radioactivity/mass-ratio). 18F-Labeled methyl fluoride ([ 18F]CH 3F) was synthesized from [ 18F]F − aq and mixed with carrier F 2 in an inert neon matrix. The constituents were atomized in an electric discharge, after which a rearrangement and 18F for 19F exchange took place. [ 18F]F 2 with a specific radioactivity of up to 55 GBq/μmol is available for the labeling synthesis of tracers for positron emission tomography (PET).
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