Fluorierte Tenside und native Nano discs für die Membranproteinforschung

Abstract

Integral membrane proteins are important but challenging research subjects. Various membrane mimetics have been developed that should preserve the native structure and function of membrane proteins while rendering them amenable to biophysical, biochemical, and structural investigations. Here, we summarize recent progress with fluorinated surfactants and amphiphilic copolymers, two unconventional membrane mimetics that possess considerable advantages over canonical detergents or lipid vesicles.