Abstract
Context:Osteosarcoma is a rare malignant bone tumor, commonly occurring in the age group of 10 to 24 years. Recent reports have indicated that there is a link between fluoride exposure and osteosarcoma.Aims:The present study was planned to analyze serum levels of fluoride in patients of osteosarcoma and fluoride content of their drinking water.Settings and Design:The present study was carried out comparing 10 patients of osteosarcoma and 10 healthy volunteers (who served as controls).Materials and Methods:Serum and drinking water fluoride levels were estimated by ion selective electrode.Statistical analysis used:The data were computed as mean ± SD and Student’s t test was applied.Results:Both, the serum and drinking water fluoride levels, were significant by higher in patients with osteosarcoma as compared to controls (P > 0.05, P > 0.001, respectively).Conclusions:These results suggest a link between fluoride exposure and osteosarcoma.
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