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Abstract
HighlightsA kind of multifunctional silicon-based theranostic agent is fabricated and exploited for imaging-guided tumor-targeted photothermal therapy.The obtained gold nanoparticles-decorated fluorescent silicon nanorods featuring high photothermal conversion performance and good photothermal stability enable a total ablation of tumors and prolong the survival time of mice.
Highlights
Along with tremendous advances in cancer nanomedicine, more challenges such as the complexity and heterogeneity of tumors are gradually realized [1, 2]
Zero-dimensional fluorescent silicon nanoparticles with robust photostability and negligible toxicity have been extensively explored for real-time and long-term bioimag‐ ing [18,19,20,21,22,23]
To label integrin α5β1, the cells were cultured with 100 μg mL−1 poly(ethylene glycol) (PEG)-Au@silicon nanorods (SiNRs), RGD-PEG-Au@SiNRs, or RGD-PEG-Au@SiNRs in the presence of 1 μM of c(RGDyC) in a binding buffer (37 °C, 5% CO2) for 1 h. (For the blocking group, cells were pretreated with 1 μM of c(RGDyC) for 30 min.) After incuba‐ tion, cells were washed by phosphate buffer saline (PBS) three times
Summary
Along with tremendous advances in cancer nanomedicine, more challenges such as the complexity and heterogeneity of tumors are gradually realized [1, 2]. Great efforts have recently been devoted for the exploitation of new-type one-dimensional fluorescent silicon nanostruc‐ tures, i.e., silicon nanorods (SiNRs), which have drawn intensive attentions in optoelectronics and photovoltaics because of their unique optical properties (e.g., longer Auger lifetimes and higher carrier multiplication quan‐ tum yield than zero-dimensional silicon nanoparticles) [28,29,30,31]. Unique optical and special biobehavioral properties make fluorescent SiNRs promising nanotheranostic agent for cancer diagnosis and therapy, which remains vacant up to present. The agent is made of gold nanoparticles-decorated fluorescent silicon nanorods (Au@SiNRs), which are prepared via in situ growth AuNPs on microwave-synthesized SiNRs. Remarkably, the obtained Au@SiNRs feature high photothermal conversion performance (photothermal conversion efficiency: ~ 43.9%) and robust photothermal stability (preserving the same temperature elevation curve and morphology after five cycles of NIR laser irradiation), suitable for photoa‐ coustic (PA) and infrared thermal imaging. One-time irradiation with an 808-nm NIR laser at a low power den‐ sity (0.8 W cm−2) induces the total ablation of tumors and drastically prolonged survival time of mice
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