Abstract
A novel fluorescent sensor CHT based on the excellent optical properties of coumarin derivatives was designed. It was synthesized by Schiff base reaction connected by 7-(N,N-diethylamino) coumarin-3-aldehyde and 2-hydrazinobenzothiazole. The sensor CHT exhibited a significant fluorescence quenching at 540 nm upon the addition of Cu2+ ions. And the sensor exhibited good sensitivity, fast response time, high selectivity for Cu2 + ions in the presence of other important relevant metal ions. In addition, fluorescent sensor CHT was successfully applied for fluorescent imaging of Cu2+ ions in A549 and MCF-7 cells, demonstrating its potential applications in live cell imaging.
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