Abstract
Zinc ion is one of the essential trace elements of the human body. It is involved in the synthesis of over a hundred enzymes and is also associated with the activities of nearly two-hundred enzymes. Zinc ion is also widely involved in the metabolism of lipids, saccharides, nucleic acids, enzymes, proteins, and gene transcription. It has been implicated in physiological processes associated with many diseases, such as diabetes and Alzheimer’s disease, and also affects human growth, development, appetite, and taste. Therefore, developing methods for efficient and rapid detection of zinc ions in vitro and in vivo are quite significant. Fluorescent probe can be an excellent method for detecting and imaging zinc ion because of its simple operation, fast response, high sensitivity, and good selectivity. In the past decades, a large number and variety of fluorescent probes for sensing zinc ions have been developed. In this chapter, the response mechanism, recognition group, sensing type, targeted imaging, and applications of Zn(II)-selective fluorescent probes are introduced separately.
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