Abstract
Reactive oxygen species (ROS) are the prize we are paying for an energy-efficient life under oxygen. They play a role in many diseases such as atherosclerosis, hypertension, ischemiareperfusion injury, inflammation, type-2 diabetes, certain neurodegenerative diseases, even cancer and, certainly, aging (Kohen & Nyska, 2002). Among these ROS are several radicals such as the hydroxyl, peroxy, alkoxy as well as the superoxide anion radical (Boveris, 1977). Direct measurement of the radicals is hampered by their short half lifes in the range of nanoto microseconds. They can, however, be trapped by addition to nitrones leading to relatively stable nitroxides with t1⁄2 of minutes (Janzen, 1971). Respiring mitochondria are a major source of ROS, particularly of the superoxide anion radical, which is formed in complexes I and III (Cadenas & Davies, 2000; Droge, 2002; Inoue et al., 2003; Turrens, 2003).
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
