Abstract
Fluorescent molecular force probes have been developed for rheology and mechanobiology. Single covalent bond is generally cleaved by nano-Newton force, which has been confirmed by the analyses of AFM and optical tweezers. To quantitatively evaluate stress concentration in stretched polymeric materials or biological systems before they break, pico- Newton force must be detected at molecular scale, and therefore molecular force probes based on a bond-breaking mechanism cannot be used for this purpose. Here we have explored flexible force probes that show fluorescence response by a conformational change of flapping π-conjugated molecules (FLAP), which have the potential to realize fluorescence response to pico-Newton forces. In this presentation, a series of FLAPs synthesized in our laboratory will be introduced in connection with the force mapping technology.
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