Abstract
Highly fluorescent hollow ZrO2@CdTe nanoparticles (NPs) were synthesized efficiently via thehydrothermal method. By changing the hydrothermal time of ZrO2@CdTe NP, the peaks of fluorescence spectra measured at fluorescent excitation of 330nm were at540nm, 590nm, and 640nm, respectively. Hollow ZrO2 NPs have a uniform core-shell structure with the size of 178 ± 10nm and shell of 19 ± 4nm. The as-prepared yellow-ZrO2@CdTe NPs were used to develop lateral flow assay (LFA) for the sensitive and qualitative detection of C-reactive protein (CRP). The visual limit of detection of the LFA for the CRP antigen was 1 μg/L within 20min, which is1000-fold lower than that ofcolloidal gold-based LFA. In addition, a multiplex lateral flow assay (mLFA) was developed using the as-prepared green and red-ZrO2@CdTe NPs for the simultaneous, specific, sensitive, and qualitative detection of CRP and troponin T (cTnT). The visual limits of detection of CRP and cTnT in mLFA were 10μg/L and 0.1mg/L, respectively. The excellent performance of ZrO2@CdTe NPs should facilitate their application in point-of-care technology for the detection of other biomarkers.
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