Abstract
AbstractFluorescent cyclic peptides are excellent chemical scaffolds to build optical agents for molecular imaging. In addition to their favorable physicochemical properties, they can be modified with multiple organic fluorophores and generate useful probes for biological assays targeting specific proteins, namely receptors or enzymes. In this article, we review recent advances in the synthetic approaches for the preparation of fluorescent cyclic peptides as well as some of their applications in biological imaging, from in vitro live‐cell imaging studies to in vivo characterization of preclinical models.
Highlights
Peptides have been increasingly employed as chemical scaffolds to build molecular imaging agents
O'Shea et al recently reported a chemical approach to enhance the signal-to-noise ratios of fluorescent cyclic peptides by conjugating them to NIR activatable fluorophores that preferentially emit in acidic microenvironments (Figure 4B).[123]
The notable physicochemical and biological properties of cyclic peptides make them interesting scaffolds for the preparation of molecular imaging agents
Summary
Citation for published version: Mendive Tapia, L, Wang, J & Vendrell Escobar, M 2020, 'Fluorescent cyclic peptides for cell imaging', Peptide Science.
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