Abstract
Fluorescent dyes are widely used in histological studies and in intraoperative surgery, including against prostate cancer (PC), which is one of the most common types of cancerous tumors among men today. Targeted delivery of fluorescent conjugates greatly improves diagnostic efficiency and allows for timely correct diagnosis. In the case of PC, the protein marker is prostate specific membrane antigen (PSMA). To date, a large number of diagnostic conjugates targeting PSMA have been created based on modified urea. The review focuses on narrowly targeted conjugates selectively binding to PSMA and answers the following questions. Which fluorescent dyes are already in use in the field of PC diagnosis? What factors influence the structure-activity ratio of the final molecule? What should be considered when selecting a fluorescent tag to create new diagnostic conjugates? And what can be offered in this field to date?
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