Fluorescent boronate-based polymer nanoparticles with reactive oxygen species (ROS)-triggered cargo release for drug-delivery applications.

Eliézer Jäger,Anita Höcherl,Miroslav Šlouf,Martin Hrubý,Olga Janoušková,Petr Štěpánek,Miloš Netopilik,Jiří Pánek,Alessandro Jäger,Karel Ulbrich,Rafał Konefał

doi:10.1039/c6nr00791k

Abstract

A new drug-delivery system of polymer nanoparticles (NPs) bearing pinacol-type boronic ester and alkyne moieties displaying triggered self-immolative polymer degradation in the presence of reactive oxygen species (ROS) with the capability of cellular imaging is presented. The NPs specifically release their drug cargo under concentrations of ROS that are commonly found in the intracellular environment of certain tumors and of inflamed tissues and exhibit significant cytotoxicity to cancer cells compared to their non-ROS-responsive counterparts.

Highlights

Eliézer Jäger,* Anita Höcherl,* Olga Janoušková, Alessandro Jäger, Martin Hrubý, Rafał Konefał, Miloš Netopilik, Jiří Pánek, Miroslav Šlouf, Karel Ulbrich and Petr Štěpánek
The NPs release their drug cargo under concentrations of reactive oxygen species (ROS) that are commonly found in the intracellular environment of certain tumors and of inflamed tissues and exhibit significant cytotoxicity to cancer cells compared to their non-ROS-responsive counterparts
An increasing amount of data indicates that ROS such as H2O2 are a component of cell signaling pathways that are necessary for the growth, development, and fitness of living organisms.[7]

Summary

Introduction

Eliézer Jäger,* Anita Höcherl,* Olga Janoušková, Alessandro Jäger, Martin Hrubý, Rafał Konefał, Miloš Netopilik, Jiří Pánek, Miroslav Šlouf, Karel Ulbrich and Petr Štěpánek. The NPs release their drug cargo under concentrations of ROS that are commonly found in the intracellular environment of certain tumors and of inflamed tissues and exhibit significant cytotoxicity to cancer cells compared to their non-ROS-responsive counterparts.

Results

Conclusion