Abstract
AbstractThe interaction between naproxen and yeast DNA was studied using fluorescence spectrometry and ultra‐violet (UV) spectrometry. The addition of yeast dsDNA to naproxen solution resulted in a strong fluorescence quenching. Both the Stern‐Volmer and the Scatchard plots of the fluorescence quenching showed a curve with two slopes and a threshold DNA concentration of about 100 µmol·L−1. The interaction between naproxen and the dsDNA was found to be a groove binding mode by UV spectra, the influence of ion strength and I− quenching effect. This mode was independent on DNA concentration. However, the increase in DNA concentration changed the binding constant K of naproxen to yeast dsDNA and the number of binding sites in DNA base pairs (n).
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
