Abstract
The reactions of 2-chloropyrimidine with methylamine, ethylamine and piperidine gave the corresponding 2-N-methylamino-, 2-N-ethylamino- and 2N- piperidinopyrimidines, respectively. The fluorescence properties of these alkylamino derivatives in chloroform, ethyl acetate, carbon tetrachloride, acetone, ether, ethanol and methanol were studied. All the alkylamino derivatives showed the highest fluorescence intensity in polar protic solvents; thus 2-N-methylaminopyrimidine (highest fluorescence intensity at 377 nm when excited at 282 nm) and 2-N-ethylaminopyrimidine (highest fluorescence intensity at 375 nm, when excited at 286 nm) showed the highest fluorescence in methanol. In ethanol, 2-N-piperidinopyrimidine showed a fluorescence peak at 403 nm when excited at 360 nm and in chloroform it fluoresced at 392 nm when excited at 356 nm.
Highlights
Science and technology are progressing very fast but advances in science, especially in the fields of biology, chemistry and medicine, are sometimes limited by the availability of suitable extremely sensitive analytical techniques
For example, tryamine, found in animal urine and tissues, can be determined by first condensing it with formaldehyde, followed by oxidation to give a fluorescent product [4], which is estimated by this technique
The high fluorescence intensity observed in ethanol and methanol is probably due to hydrogen bonding by the solvents
Summary
Science and technology are progressing very fast but advances in science, especially in the fields of biology, chemistry and medicine, are sometimes limited by the availability of suitable extremely sensitive analytical techniques. The fluorescence properties of these alkylamino derivatives in chloroform, ethyl acetate, carbon tetrachloride, acetone, ether, ethanol and methanol were studied. 2-N-piperidinopyrimidine showed a fluorescence peak at 403 nm when excited at 360 nm and in chloroform it fluoresced at 392 nm when excited at 356 nm.
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