Abstract
Modalities All tissues fluoresce due to the presence of fluorescent chromophores (fluorophores) within them. The commonly fluorophores are NADH, collagen, elastin and cofactors such as flavins (FAD, FMN). FS can detect these substances and provide characteristic spectra that reflect biochemical changes within the tissues. There are three main ways to obtain fluorescence, autofluorescence (induced by UV light) Laser-induced and enhanced/dye which can be by either topical or systemic application of 5-aminolaevulinic acid (5-ALA). Dysplastic and malignant tissues, as well as having different spectral characteristics, tend to have increased red fluorescence and decreased green fluorescence. Therefore, significant increase in the red/green fluorescence ratio is an accurate predictor of dysplasia and malignancy.
Highlights
Colin Hopper*Address: UCLH Head and Neck Centre, London, UK * Corresponding author from 1st Scientific Meeting of the Head and Neck Optical Diagnostics Society London, UK. 14 March 2009
1S1.pdcientific Meeting of the Head and Neck Optical Diagnostics Society Colin Hopper, Adel K El-Naggar, Tahwinder Upile, Waseem Jerjes and HJCM Sterenborg Publication of this supplement was made possible with support from KARL STORZ Endoskope Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/
Fluorescence spectroscopy (FS) is a non-invasive technique which can be used to distinguish normal from abnormal tissue and can identify at an early stage dysplastic changes as well as provide clinical screening in real time without the need for tissue removal or processing
Summary
Address: UCLH Head and Neck Centre, London, UK * Corresponding author from 1st Scientific Meeting of the Head and Neck Optical Diagnostics Society London, UK. 14 March 2009. Address: UCLH Head and Neck Centre, London, UK * Corresponding author from 1st Scientific Meeting of the Head and Neck Optical Diagnostics Society London, UK. Published: 28 July 2009 Head & Neck Oncology 2009, 1(Suppl 1):P3 doi:10.1186/1758-3284-1-S1-P3. 1S1.pdcientific Meeting of the Head and Neck Optical Diagnostics Society Colin Hopper, Adel K El-Naggar, Tahwinder Upile, Waseem Jerjes and HJCM Sterenborg Publication of this supplement was made possible with support from KARL STORZ Endoskope Meeting abstracts – A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/pdf/
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