Abstract
In the limited terms of neonatal respiratory distress syndrome (RDS), neonatal respiratory outcome has been correlated with fluorescence polarization assays of amniotic fluid. Respiratory outcome in terms of the severity of RDS, as well as the duration of respiratory support, has not.During a 4-year period, 179 patients delivering within 72 h of amniotic fluid analysis by fluorescence polarization were reviewed for neonatal respiratory outcome. The degree of respiratory distress and respiratory support was determined and stratified by TDx-FLM values.Overall risk of RDS for patients delivering within 72 h of fluid sampling was 13.8%. Risk of RDS for FLM values >50 mg/g was 5.3%, with an average duration of respiratory support of 2.1 days. No long-term RDS-related sequelae were encountered in samples in which FLM values exceeded 50 mg/g. RDS occurred in 4.0% of patients with FLM >70 mg/g; in all but one case, however, simultaneous chromatographic analysis (lecithin/sphingomyelin and phosphotidylglycerol) in...
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