Abstract
SummaryFluorescence Lifetime Imaging Ophthalmoscopy (FLIO) allows in vivo measurement of autofluorescence lifetimes of natural retinal fluorophores upon laser excitation. Beyond fluorescence intensity, lifetimes provide further information about the metabolic state of the retina as they are dependent on micro environmental factors.Fluorescence lifetimes were investigated in healthy retinae and compared with retinal diseases such as retinal artery occlusion, geographic atrophy due to age related macular degeneration, central serous chorioretinopathy, Stargardt disease, and choroideremia.Retinal autofluorescence lifetimes feature disease specific patterns. They allow identifying differences within retinal deposits and changes of local or systemic metabolic conditions over time. Thereby, FLIO provides a promising tool for investigation of retinal metabolic changes. Especially neurodegenerative diseases associated with intracellular deposits shall be further investigated. As FLIO is a non invasive imaging technique which is easy to apply it might qualify as a screening technique for early detection of retinal changes also in neurodegenerative diseases.
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