Abstract
The molecular dynamics and protein interactions in living cells remain poorly understood despite their importance to several cellular processes. RNA molecules, for example, play a major role in many processes, from encoding and regulating gene expression to catalyzing biological reactions. Alterations of the metabolism of RNAs and RNA-binding proteins are involved in neurodegenerative diseases, such as ALS in neuronal cells. In particular, the connection between biomolecular dynamic processes and cellular function/organization is still unclear.Here, we propose a new class of Fluorescence Fluctuation Spectroscopy (FFS) techniques performed with a novel single-photon-avalanche-diode (SPAD) array detector to better decipher molecular dynamics, interactions and structural changes directly in living cells with microsecond time resolution.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
