Abstract
Fluoranthene and pyrene are potent cocarcinogens when applied together with benzo[ a]pyrene (BaP) on mouse skin. In this study the effect of fluoranthene, pyrene and phenanthrene on the formation of BaP—DNA adducts in mouse skin was investigated. Co-application of either fluoranthene or pyrene with [ 3H]BaP resulted in an average increase in the level of [ 3H]BaP—DNA adducts of 56% to 66%, respectively, as compared to [ 3H]BaP alone. Only minor differences were observed in the ratio of (±) anti- to (±) syn-benzo[ a]pyrene diol epoxide—DNA adducts between experimental groups. An average 17% decrease in the formation of [ 3H]BaP—DNA adducts was observed upon co-application of [ 3H]BaP on mouse skin with phenanthrene. These data suggest a correlation between the observed increase in tumorigenicity of BaP in the presence of either fluoranthene or pyrene and an increase in the formation of (±) anti-benzo[ a]pyrene diol epoxide—DNA adducts.
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