Fluidity of onion-like fullerenes in mice after a functionalization modification

Abstract

Water-soluble onion-like fullerene(OLF)derivatives were prepared by chemical bonding of L-cysteine,an important amino acid in organisms,to OLFs.The L-cysteine OLFs were characterized by SEM,XRD,IR,TGA and XPS.Results showed that hydrophilic groups added to the surface of OLFs such as-OH and-NH3 made L-cysteine OLFs good water-soluble derivatives.Experiments in mice demonstrated that the water-soluble fullerene derivatives were well distributed in the histolytic organism because of their excellent solubility and fluidity in humoral liquid.