Abstract
AbstractDuring 6 min exercise on a bicycle ergometer the volume of the leg in normal males increased so as to indicate, after correction for increased regional blood volume, an average trans‐capillary fluid loss into the leg muscles of 19, 31, and 45 ml/kg tissue at light (300 kpm/min), moderate (900 kpm/min), and heavy (1200–1500 kpm/min) work load. The total fluid loss into the active muscle mass was calculated to comprise about 1100 ml during heavy work. Since the concomitant decrease of plasma volume was 600 ml, it follows that some 500 ml of fluid must have entered the circulatory system during the work. The study indicated that this compensatory fluid gain was accomplished by absorption of extravascular fluid from inactive tissues and partly caused by osmosis resulting from work induced arterial hyperosmolality (average increase 22 mOsm/kg H2O). Fluid absorption from inactive tissues was studied in experimental animals during exercise and in resting humans during arterial hyperosmolality produced by intravenous hypertonic infusions. The investigations suggested that at least half of the fluid gain to the circulatory system in heavy exercise could be ascribed to the increased arterial osmolality and the remainder to a reflex decrease of capillary pressure.
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