Fluid therapy strategy for acute lung injury and acute respiratory distress syndrome

Abstract

Background High permeability pulmonary edema is the basic pathophysiological characteristics of acute lung injury and acute respiratory distress syndrome (ALI/ARDS),the degree of which is directly bound up with the prognosis of ALI/ARDS. Objective Rational fluid therapy for ALI/ARDS patients can improve pulmonary edema and mortality. Content In this article,we reviewed the controversial issues,such as:① the selection of a conservative or a liberal strategy of fluid therapy,② the selection of fluid type.We also summarized the research progress in this field,such as different treatment and monitoring indicators for distinct stage in the progress of ALI/ARDS in the past few years. Trend Future research will focus on exploring specific fluid therapy strategy for ALI/ARDS during various pathophysiological stages,and seeking effective and sensitive monitoring indicators to guide the selection and adjustment of fluid therapy strategy for ALI/ARDS. Key words: Acute lung injury; Acute respiratory distress syndrome; Fluid therapy