Abstract
Developing cartilage constructs with injectability, appropriate matrix composition, and persistent cartilaginous phenotype remains an enduring challenge in cartilage repair. Fourteen patients with minor contour deformity were treated with fluid cartilage filler gently injected as autologous fluid graft in deep planes of defect of the nose that were close to the bone or the cartilage. A computerized tomographic scan control was performed after 12 months. Pearson’s Chi-square test was used to investigate differences in cartilage density between native and newly formed cartilages. The endpoints were the possibility of using fluid cartilage as filler with aesthetic and functional improvement and versatility. Patients were followed up for two years. The constructs of fluid cartilage graft that were injected in the deep plane resulted in a persistent cartilage tissue with appropriate morphology, adequate central nutritional perfusion without central necrosis or ossification, and further augmented nasal dorsum without obvious contraction and deformation. This report demonstrated that fluid cartilage grafts are useful for cartilage regeneration in patients with outcomes of rhinoplasty, internal nasal valve collapse, and minor congenital nose aesthetics deformity.
Highlights
The rhinoplasty is mainly a procedure for the reduction of the size, but sometimes the need of enlargement for defects or irregularities, in primary or secondary rhinoplasties
For this piece of research, we examined clinical results obtained by the use of fluid cartilage as filler, and we analysed the in vivo performance of human chondrocytes (HCs) contained in fluid cartilage in cell brick-enriched saline solution evaluating the persistence of a stable chondrogenic phenotype
Haematoxylin–eosin-stained sections (Figure 3A–D) of cartilage samples obtained from the different procedures showed, in each group, the presence of connective tissue consisting of a dense matrix and HCs embedded
Summary
The rhinoplasty is mainly a procedure for the reduction of the size, but sometimes the need of enlargement for defects or irregularities, in primary or secondary rhinoplasties. To rebuild the hard tissue defects of the nose, the first choice is the autologous cartilage. Sometimes to aggregate using fibrine glue or patient’s own blood, or to implant them, it is necessary to incise and dissect the nose tissues as classic rhinoplasty. To avoid these invasive procedures, especially when we do not need large quantities of an implant, an easier procedure is the use of more fluid cartilage derived by shaving with scalpel n. To avoid these invasive procedures, especially when we do not need large quantities of an implant, an easier procedure is the use of more fluid cartilage derived by shaving with scalpel n. 15, which we can manipulate as a filler with injection by needles between 21–18 gauge, or equivalent size cannulas
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
