Abstract
Nineteen patients were studied during the first 4 days after withdrawal from alcohol. Plasma vasopressin was raised ( P < 0.05) and fluid retention occurred ( P < 0.05), with falls in haematocrit ( P < 0.01) and calculated plasma osmolality ( P < 0.02), which were consistent with expansion of plasma volume. Despite these changes mean total body water was within normal limits although there were substantial inter-individual variations. There was no correlation between any measure of fluid balance and the severity of withdrawal symptoms.
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