Abstract
Publisher Summary This chapter describes recent progress in the fluctuation analysis of Na and K channels in excitable membranes, a short introduction to the principles, and general properties of two-state channels in the analysis of Na and K current fluctuations. The fluctuation analysis of Na and K channels in excitable membranes is restricted to an investigation of current fluctuations produced by the random opening and closing of individual channels. The analysis yields results on the conductance of a single channel, on its gating properties, on the actions of external blocking particles, and on the mechanism of channel modification. In the fluctuation analysis of ionic channels, it is commonly assumed that the kinetics of channel opening and closing are so fast that each channel produces essentially a rectangular current trace. Multichannel-fluctuation analysis and single-channel recordings are complementary methods, and their combined use will undoubtedly reveal further details about ionic-membrane channels in the future.
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