Abstract
The ergosterol-depleting antifungal fluconazole, when given at concentrations not affecting growth, inhibited pseudohyphal growth in Saccharomyces cerevisiae, a genetically tractable fungus closely related to the human pathogen Candida albicans. These results suggest that S. cerevisiae could serve as a useful genetic system to study the morphogenetic effects induced by azoles in pathogenic yeast.
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