Abstract
A flow-injection method is described for the determination of acetaminophen (paracetamol) (linear range 0.8.100 gmg ml −1 based on its oxidation with 2-iodylbenzoate in acid medium to produce a yellow-orange compound, believed to be N-acetyl-1,4-benzoquinoneimine, which is monitored at 445 nm. The sample throughput is 360 h −1. The precision (R.S.D) of determination was 0.5−2%. The method was applied to the determination of acetaminophen in drug formlations, and evaluated by analyzing spiked sample solutions, a mean recovery of 1006% (range 96.3−105.2%) being obtained. No interference was observed from the common exicipients of drugs and other active substances, e.g., dipyrone, acetylsalicylic acid, salicylamide and oxyphenbutzone. Te possible application of the proposed method in content uniformity test and drug dissolution studies is indicated. Comparison of the present method with a liquid chromatographic method for acetaminophen determination gave a mean difference of 1.2% (range 0.4−2.4%).
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