Abstract
A flow injection spectrophotometric method is described for the determinaiton of sulphonamides
 in aqueous and biological samples. The method is based on the oxidative coupling reaction of 4-amino-N,
 N-diethylaniline with sulphonamide drugs in the presence of potassium dichromate as oxidizing agent.
 Intense violet, water soluble dye was obtained which has a maximum absorption at 550nm,. Linear
 calibration graphs were obtained for different sulphonamides with a molar absorpitivity of 4200-5270 l mol-1 cm-1
 and a relative standard deviation less than 0.56%. The proposed method has proved to be highly sensitive (detection limit range 0.30-0.63 μg ml-1 sulphonamide) and accurate (recovery % was 98.2-101.2%). The nature of the coloured dye and its stability constant were determined. The method was applied successfully to the determination of sulphonamide drugs in pharmaceutical preparations, blood and urine samples.Keywords: FIA, Spectrophotometer 4-amino-N, N-diethylaniline
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