Abstract
A single optosensing device based on lanthanide-sensitized luminescence was developed for determination of p-aminobenzoic acid (PABA). The method is based on the formation of a complex between PABA and Tb(III) immobilized on the solid phase (QAE A-25 resin) placed inside the flow cell. NaCl (1M) was used as carrier solution and HCl (0.05M) as eluent. The sample solutions of PABA (100μL) containing Tb(III) and buffered at pH = 6.0 were injected into the carrier stream and the luminescence was measured at λ (ex) = 290nm and λ (em) = 546nm. The method shows a linear range from 0.2 to 6.0μgmL(-1) with an RSD of 1.2% (n = 10) and a sampling frequency of 22h(-1). A remarkable characteristic of the method is its high selectivity which allows it to be satisfactorily applied to the analysis of PABA in pharmaceutical samples without prior treatment.
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